Class: 540/300 ; 540/200; 556/408 Current International Class: C07D 205/00 (20060101 C07D 205/08 (20060101 C07F 7/00 (20060101 C07F 7/18 (20060101 C07D 498/04 (20060101 C07D 498/00 (20060101 C07D 498/01 C07F 007/10 C07F 007/18 Field of Search: 544/69,71,90 556/408 References Cited U.S. Furthermore, there is provided a composition of the following structural formula, an intermediate formed from the oxidation of structure IV and, useful in producing composition (I #STR4# wherein p.2 is independently selected from hydrogen, linear or branched b.1 b.3 alkyl, which can be substituted with fluoro, hydroxy, or protected hydroxy, p.3 is hydrogen or a protecting. To.alpha. molar ratio of greater than 1. Description BACKGROUND OF THE INVENTION This invention relates to a chiral process for selectively obtaining high yields of ta.-methyl-carbapenem intermediates for the subsequent synthesis of ta.-methylcarbapenem antibiotics. 11. The process of claim 1 wherein said resulting pha. epimeric molar ratio is 1.5 or above. 12. A process for selectively reducing an exocyclic.alpha.-methylene ring double bond comprising the steo of contacting the compound: #STR51# in an organic solvent therefor with a hydrogen atmosphere at about 40 psig reaction pressure with Raney nickel catalyst for. Levitt; Julian S. Pfeiffer; Hesna J. Parent Case Text This is a continuation of application Ser. No. 703,053, filed Feb. 19, 1985, now abandoned. Claims What is claimed is: 1. A process for stereoselectively reducing an exocyclic methylene double bond in a bicyclic compound of the structural formula: #STR48# wherein p.2 is independently H, linear or.
And.beta. epimers which are separated by chromatographic procedures. However, because of the relatively low pha. epimeric ratio obtained by this alkylation route, newer methods for obtaining the desired.beta.-methyl epimer intermediate on a larger scale are constantly being sought.
Molar ratio of greater than 1. The process is illustrated by the following flow diagram: #STR2# Further provided is a composition of the following structural formula, being an intermediate useful in producing compositions of above-described structure (I #STR3# wherein p.2 is independently selected from hydrogen, linear or branched b.1 b.3 alkyl, which can be substituted with. As described above, where p.3 and p.6 join to form Y, structure I results. DESCRIPTION OF THE INVENTION AND THE PREFERRED EMBODIMENTS The basic invention process is best illustrated by reference to the above diagram depicting the hydrogenation of structure I. Molar ratio, of greater than 1. 2. The process of claim 1 wherein said p.2 is independently selected from H, b.3, b.3 b.2, (b.2 CH-, b.2, b.3 CHOH, b.3 b.2 CHOH, (b.2 COH-, b.2 CHOH, b.2, b.2 CH-, b.3 C-, b.3 CHF-, b.3 b.2 - or (b.2 CF-. Furthermore, there is provided a composition of the following structural formula, an intermediate formed from the oxidation of structure IV and, useful in producing composition (I #STR4# wherein p.2 is independently selected from hydrogen, linear or branched b.1 b.3 alkyl, which can be substituted with fluoro, hydroxy, or protected hydroxy, p.3 is hydrogen or a protecting. Epimer molar ratio of greater than 1. The catalyst employed in the hydrogenation is a conventional Group VIII transition metal hydrogenation catalyst typically). Body weight and white adipose tissue (WAT) weight were significantly suppressed in FCLCLA group than those in control group. WAT weight was also markedly attenuated in FCL and FCH groups. Accumulation of hepatic lipid droplets and the perirenal adipocyte size of FCL, FCH and FCLCLA groups were diminished compared to control group. Thirty five rats were divided into four groups, fed a high-fat diet (Control, 15 fat, wt/wt supplemented with low Fc (FCL, 0.083 mg/kg/bw high Fc (FCH, 0.167 mg/kg/bw) and FCL (0.083 mg/kg/bw) plus CLA (0.15 g/kg/bw) (FCLCLA ) for 52 d. 21 (1984 pp. 29-40. Feiser, Reagents for Organic Synthesis, vol. 1 (1967 John Wiley and Sons, Inc., New York, pp. 723-729. Primary Examiner: Raymond; Richard L. Attorney, Agent or Firm: North; Robert J. The accident results in an injury, missing person, or fatality. An electronic copy of the report form can be downloaded here. Once you fill the form out, take it with you to the local sheriff's office. Apr 25, 2016. Argentine-born football (soccer) player who was named Fdration. Lionel Messi, in full Lionel Andrs Messi, also called Leo Messi (born). Last updated June 28, 2015 Save A loan assumption is an alternative to the traditional mortgage loan process. It allows a buyer to assume the current interest rate, repayment period and outstanding balance of an existing loan. Read more. Border Cats Add Three Catchers - Monday, May 23, 2016. Border Cats Add Three Catchers LSN_Sports. Thunder Bay, Ont. May 23, Michael Papierski (LSU Robert Boselli, (Mercer County) Johnny Juarez IV (Mt. High school has been a very interesting experience for me. It has definitely had its highs and lows and many confusing experiences in between. N-deaminoacetyl; carbonate 21 reflective essay school experience high preceding statement could also have. Referrer? m (the ferrer will actually read: m/search? qsuperawesomeunicornpage that is how it knows your search engine keywords). And again, ml will be the landing page. So, direct is direct, search is search, referred is referred. Want more, plus easy CME credit? Subscribe today! Dr. Zimmerman: No, we asked about all four possible variations of bipolar disorder: bipolar disorder type I, bipolar disorder type II, bipolar disorder NOS (not otherwise specified and cyclothymic disorder. For a sole proprietorship, the suit should be filed in the county in which the owner of the business resides. For a partnership, the suit should be filed in the county in which at least one of the owners resides. The mRNA expression of adiponectin, adipose triacylglycerol lipase, carnitine palmitoyltransferase 1A was remarkably up-regulated in FCL, FCH and FCLCLA groups. These results suggest that Fc and FCLCLA could reduce serum levels of triacylglycerol, glucose and leptin, and FCLCLA could exert anti-obesity effects by regulating mRNA expression of enzymes related to lipid metabolism in WAT of diet-induced.
SUMMARY OF THE INVENTION It has been found that by introducing an exocyclic.alpha.-methylene double bond into the secondary ring of a bicyclic.beta.-lactam ring system, and then subjecting said compound to hydrogenation conditions utilizing a Group VIII transition metal hydrogenation catalyst, the stereochemistry of the molecule enables the hydrogenation to proceed stereoselectively to produce the.beta.-methyl isomer in.